|
Year |
Acronym |
Title (Click for Details) |
n |
F-up (yrs) |
Primary treatments compared |
| |
HOPE |
Heart Outcomes Prevention Evaluation Study |
9,297 |
5 |
Ramipril vs placebo |
| |
PART2 |
Prevention of Atherosclerosis with Ramipril Trial |
617 |
4 |
Ramipril vs placebo |
| |
QUIET |
Quinapril Ischaemia Event Trial |
1750 |
2 |
Quinapril vs placebo |
| |
SCAT |
Simvastatin/Enalapril Coronary Atherosclerosis Trial |
460 |
5 |
Enalapril vs placebo |
| |
PREVENT |
Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial |
825 |
3 |
Amlodipine vs placebo |
| |
SYST-EUR |
Systolic Hypertension in Europe Trial |
4695 |
2 |
Nitrendipine vs placebo |
| |
ABCD |
Appropriate Blood Pressure Control in Diabetes Trial |
470 |
5 |
Target DBP < 75 mmHg vs < 90 mmHg |
| |
HOT |
Hypertension Optimal Treatment Study |
18,790 |
4 |
Target DBP < 80 mmHg vs < 85 or < 90 mmHg |
| |
UKPDS-HDS |
UK Prospective Diabetes Study—Hypertension in Diabetes Study |
1148 |
8 |
Target DBP < 85 mmHg vs < 105 mmHg |
| |
CAPPP |
Captopril Prevention Project |
10985 |
6 |
Captopril vs beta-blocker (not specified) or diuretic (not specified) |
| |
STOP-2 |
Swedish Trial in Old Patients with Hypertension |
6614 |
5 |
Enalapril or lisinopril vs felodipine or isradipine vs atenolol or metoprolol or pindolol or hydrochlorothiazide + amiloride |
| |
UKPDS-HDS |
UKPDS - Hypertension in Diabetes Study |
1148 |
4 |
Captopril vs atenolol |
| |
INSIGHT |
International Nifedipine GITS Study: Intervention as a Goal for Hypertension Therapy |
6,321 |
4 |
Nifedipine GITS vs hydrochlorothiazide + amiloride |
| |
NICS—EH |
National Intervention Cooperative Study in Elderly Hypertensives |
429 |
5 |
Nicardipine vs trichlormethiazide |
| |
NORDIL |
Nordic Diltiazem Study |
10,881 |
8 |
Diltiazem vs beta-blocker (not specified) or diuretic (not specified) |
| |
VHAS |
Verapamil in Hypertension and Atherosclerosis Study |
1414 |
2 |
Verapamil vs chlorthalidone |
| |
ABCD
—hypertensive |
Appropriate Blood Pressure Control in Diabetes Trial—hypertensive subgroup |
470 |
5 |
Enalapril vs nisoldipine |
| 2001 |
AASK1 |
African American Study of Kidney Disease and Hypertension |
1150 |
5 |
Ramipril vs amlodipine vs metoprolol, more vs less |
| 2001 |
ABCD |
Appropriate Blood Pressure Control in Diabetes Trial - non-hypertensive subgroup |
480 |
5 |
Enalapril vs nisoldipine, more vs less |
| 2001 |
CONVINCE2 |
Controlled Onset Verapamil Investigation of Cardiovascular Endpoints Trial |
15000 |
5 |
Verapamil vs hydrochlorothiazide or atenolol |
| 2001 |
ELSA |
European Lacidipine Study on Atherosclerosis |
2250 |
4 |
Lacidipine vs atenolol |
| 2001 |
IDNT |
Irbesartan Diabetic Nephropathy Trial |
1650 |
3 |
Irbesartan vs amlodipine vs placebo |
| 2001 |
LIFE |
Losartan Intervention for Endpoint Reduction in Hypertension Study |
8300 |
4 |
Losartan vs atenolol |
| 2001 |
PHYLLIS |
Plaque Hypertension Lipid-Lowering Italian Study |
800 |
3 |
Fosinopril vs hydrochlorothiazide |
| 2001 |
PROGRESS |
Perindopril Protection Against Recurrent Stroke Study |
6105 |
5 |
Perindopril +/- indapamide vs placebo |
| 2001 |
RENAAL |
Randomized Evaluation of Non-Insulin-Dependent Diabetes Mellitus with the Angiotensin II Antagonist Losartan |
1500 |
4 |
Losartan vs placebo |
| 2001 |
SCOPE |
Study on Cognition and Prognosis in the Elderly |
4000 |
2.5 |
Candesartan vs placebo |
| 2001 |
SHELL |
Systolic Hypertension in the Elderly Long-term Lacidipine Trial |
4800 |
5 |
Lacidipine vs chlorthalidone |
| 2001 |
OCTAVE |
Omapatrilat Cardiovascular Treatment vs. Enalapril |
25000 |
0.5 |
Omapatrilat vs. enalapril |
| 2002 |
ANBP2 |
Second Australian National Blood Pressure Study |
6000 |
5 |
Enalapril vs diuretic (unspecified) |
| 2002 |
DIAB-HYCAR |
Diabetes Hypertension Cardiovascular Morbidity-Mortality and Ramipril Trial |
4000 |
3 |
Ramipril vs placebo |
| 2002 |
EUROPA |
European Trial on Reduction of Cardiac Events with Perindopril in Ischaemic Heart Disease |
10500 |
3 |
Perindopril vs placebo |
| 2002 |
INVEST |
International Verapamil-Trandolapril Study |
22000 |
3 |
Verapamil +/- trandolapril vs atenolol |
| 2003 |
ACTION |
A Coronary Disease Trial Investigating Outcome with Nifedipine GITS |
6000 |
5 |
Nifedipine GITS vs placebo |
| 2003 |
ALLHAT3 |
Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attacks Trial |
42000 |
6 |
Lisinopril or doxazosin or amlodipine vs chlorthalidone |
| |
BENEDICT |
Bergamo Nephrologic Diabetes Complication Trial |
1200 |
3 |
Verapamil vs trandolapril vs combination vs placebo |
| 2003 |
PEACE |
Prevention of Events with Angiotensin Converting Enzyme Inhibition |
8100 |
5 |
Trandolapril vs placebo |
| 2003 |
VALUE |
Diovan Antihypertensive Longterm Use Evaluation |
14400 |
4 |
Valsartan vs amlodipine |
| 2004 |
ASCOT |
Anglo-Scandinavian Cardiac Outcomes Trial |
18000 |
5 |
Amlodipine+/-perindopril vs atenolol+/-bendrofluazide |
| 2004 |
HYVET |
Hypertension in the Very Elderly Trial |
2100 |
5 |
Indapamide +/- perindopril vs placebo |
| 2005 |
OPERA |
Omapatrilat in Persons with Enhanced Risk of Atherosclerotic Events |
12600 |
5 |
Omapatrilat vs placebo |
| 2007 |
ADVANCE |
Action in Diabetes and Vascular Disease |
10000 |
4.5 |
Perindopril plus indapamide vs placebo |
