研究了普罗布考对处于动脉粥样硬化三个不同时期：早中晚期的因链脲霉素SZ导致的糖尿病-高脂血症APA仓鼠的作用。8周龄雄性APA仓鼠腹腔注射SZ和 单用附形剂（柠檬酸盐缓冲液）作为空白对照。注射SZ或CB6周后为动脉粥样硬化早期，14周为中期，26周为晚期。试验动物被分为普罗布考治疗组和不治疗组(CBPB, SZPB, CB, SZ)。普罗布考添加入饮食治疗8周后，取每只动物大动脉评价其动脉粥样硬化损伤，采集血样经血清生化分析测定血液中过氧化脂质（LPO）的含量。在动脉粥样硬化中期，尽管无可见数据差异，普罗布考治疗能显著降低血清中总胆固醇水平，轻微降低LPO，并有减小损伤面积的趋势。普罗布考对动脉粥样硬化早期与晚期患者无显著疗效。研究表明，单用普罗布考对治疗高血糖-高脂血症动物模型的动脉粥样硬化疗效甚微。
We investigated the effect of probucol (PB) on atherosclerosis in streptozotocin (SZ)-induced diabetic-hyperlipidemic APA hamsters in three different stages, the early, middle and late stages of atherosclerosis. Male APA hamsters were injected intraperitoneally with SZ or vehicle alone (citrate buffer; CB) as a control at the age of 8 weeks. At 6 weeks after injection (WAI) of SZ or CB (the early stage), 14 WAI (the middle stage) and 26 WAI (the late stage), animals were assigned to PB treated- or non-treated groups (CBPB, SZPB, CB, SZ).After 8 weeks of PB administration with diet,the aorta was taken from each animal for assessment of atheromatous lesions and blood samples were subjected to serum biochemical analysis and the measurement of blood lipid peroxide (LPO).In the middle stage,PB treatment significantly decreased serum total cholesterol level, slightly decreased LPO, and also tended to reduce the lesion area, although no statistical difference was seen. There was no marked effect of PB treatment in the early and late stages. These findings suggest that single use of PB has little effect on atherosclerosis of a hyperglycemia-hyperlipidemia animal model.
|
|
