研究抗氧化剂普罗布考或对Ca2+拮抗剂地尔硫卓对动脉粥样硬化衰退的影响。1%胆固醇饮食饲养家兔10周后，标准饮食饲养25周（衰退期）。衰退期中，家兔分组为盐（S）组(n=8, 1 ml 盐/天)，普洛布考（P）组(n=8, 1000 mg/d 普罗布考)或普罗布考与地尔硫卓组（P+D）(n=8, 普罗布考1000 mg/d和地尔硫卓30 mg/d)。对血清和脂蛋白胆固醇，血清甘油三酯以及磷脂浓度进行测定，三组在10，15或35周时均无显著差异。致动脉粥样硬化饮食饲养10周，大动脉内膜肉眼可见动脉粥样硬化损伤增加36.6±5.6%。衰退期中，S组动脉粥样硬化损伤发生率增加48.6±6.4 %。然而在P+D和P组，其发生率分别降低24.3±5.5% (p<0.05 vs. S)和 32.3 ±5.6%。此外，动脉粥样硬化损伤发生率的降低与动脉组织脂质组成的降低相关。推断P+D或P通过降脂作用治疗衰退期动脉粥样硬化具有很好的疗效。
To clarify whether probucol, an antioxidant, or diltiazem, a Ca2+ antagonist, favorably affect the regression of established atherosclerosis, rabbits were fed a 1% cholesterol diet for 10 weeks, then a standard diet for an additional 25 weeks (regression period). During the regression period, rabbits were grouped into a saline (S) group (n=8, 1 ml saline/d), a probucol (P) group (n=8, 1000 mg/d probucol), or a probucol and diltiazem (P+D) group (n=8, probucol 1000 mg/d in diet and diltiazem 30 mg/d). We measured cholesterol in serum, lipoprotein fractions, and serum triglyceride or phospholipid concentration and found no significant differences among the three groups at 10, 15, or 35 weeks. After 10 weeks of the atherogenic diet, the ratio of macroscopic atherosclerotic lesions in aortic intima rose to 36.6 + or - 5.6%. After the regression period, the S group developed more atherosclerotic lesions (48.6 + or - 6.4%). The P+D and P groups, however, had decreased scores of 24.3 + or - 5.5% (p<0.05 vs. S) and 32.3 + or - 5.6%, respectively. Moreover, these decreased scores were well correlated with the decrease in aortic tissue lipid compositions, but not the parameters for extracellular matrices. We concluded that P+D or P therapy might be effective in regressing established atherosclerosis by removing lipid contents but not extracellular matrices.
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