| 氧化应激和动脉粥样硬化研究 |
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| 作者：Tardif J… 文章来源：Can J Cardiol. 2000 Jul;16 Suppl D:2D-4D. Review. 点击数： 更新时间：2007-5-30 |
Compelling evidence points to oxidative stress as an important trigger in the complex chain of events leading to atherosclerosis. Randomized clinical trials have not provided definitive evidence of the beneficial effect of antioxidant vitamins. Problems associated with the use of vitamins include their potential pro-oxidant effects and the decreased absorption of natural gamma-tocopherol caused by alpha-tocopherol supplements. Probucol and amlodipine are more powerful lipophilic antioxidants than vitamin E. They also do not appear to have significant pro-oxidant properties. Probucol has been shown to prevent coronary restenosis after balloon angioplasty in clinical trials. Its high density lipoprotein-lowering effect, however, prevents it from being protective against progression of coronary atherosclerosis. Slowing or reversing the atherosclerotic process with an antioxidant likely requires the use of a powerful lipophilic antioxidant that has neutral or positive effects on serum lipids when given alone or in combination with a lipid-lowering agent.
大量证据显示氧化应激在导致动脉粥样硬化复杂的事件链中起重要的触发作用。未有随机临床试验提供关于抗氧化剂维生素作用的决定性数据。与应用维生素相关的问题包括其内在的促氧化作用和添加α生育酚导致的降低天然γ生育酚吸收的作用。与维生素相比，普罗布考和氨氯地平是更强力的亲脂性抗氧化剂，而且无明显的促氧化剂作用。许多临床试验证实普罗布考能够预防管腔成形术后的冠脉再狭窄。但其对高密度脂蛋白的降低作用，限制了其在治疗冠脉粥样硬化中的应用。在延缓和逆转动脉粥样硬化进程的治疗中需要一种强力的亲脂性抗氧化剂，在单独给药或与降脂药物联用时能对血脂发挥中性或积极作用。
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