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邹云增，男，47岁，医学博士，长江学者特聘教授，博士生导师，复旦大学中山医院上海市心血管病研究所中心实验室主任，复旦大学生物医学研究院双聘教授。1984年8月本科毕业于北京医学院医学系，任青岛医学院附属医院心内科医师；1997年3月获日本东京大学医学博士学位；1997年至2000年东京大学医学部循环器内科博士后；2000年4月至2004年8月先后在东京大学医学部循环器内科和千叶大学医学部循环病态医科学任研究员。于2004年9月被聘为复旦大学特聘教授，2005年1月起任中山医院上海市心血管病研究所中心实验室主任。2005年3月评为教育部长江学者特聘教授，2005年12月获国家杰出青年科学基金和上海市优秀学科带头人。现为日本循环器学会会员，日本高血压学会会员，美国心脏协会会员，中国病理生理学会动脉粥样硬化专业委员会委员，上海医学会心血管病专业委员会动脉粥样硬化和代谢学组副组长。
研究方向为心血管疾病的基础和临床研究，主要是高血压以及心脏肥大和心力衰竭的发病机理以及血管紧张素II的作用的研究，缺血性心脏病的基因和细胞治疗的研究。在国外杂志包括Nature Cell Biology, Nature Medicine, Circulation, Circulation Research, Journal of Clinical Investigation, Journal of Biological Chemistry, Hypertension , Hypertension Research等杂志上发表了70余篇SCI收录学术论文。
承担了国家十五攻关课题，上海市白玉兰科技基金资助课题，上海市优秀学科带头人课题，国家杰出青年科学基金课题，留学回国人员启动基金课题，高等学校博士点专项科研基金课题，日本五峰生命科学国际基金研究课题，日本三共生命科学研究振兴财团课题。
CURRICULUM VITAE
Yunzeng Zou, MD, PhD
Professor
Director of Laboratory,
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University
180 Feng Lin Road, Shanghai 200032, China
TEL: 86-21-64041990 ext.2152
FAX: 86-21-54237969
Email: yzzou@zshospital.net
Education and Professional Experience:
1979-1984: Beijing Medical College
1984-1993: Department of Cardiovascular Medicine, Affiliated Hospital of Qingdao Medical College
1993-1997: University of Tokyo Graduate School of Medicine (PhD)
1997-2000: Department of Cardiovascular Medicine, University of Tokyo Graduate
School of Medicine (Postdoctoral Fellow of JSPS)
2000-2001: Department of Cardiovascular Medicine, University of Tokyo Graduate
School of Medicine
2001-2004: Department of Cardiovascular Science and Medicine, Chiba University
Graduate School of Medicine
2004.9-: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital,
Fudan University
2005.3: Chung Kong Professor of Chung Kong Scholars Programme, China
Membership of Professional Societies:
Japanese Circulation Society
Japanese Heart Failure Society
Japan Society of Hypertension
American Heart Association
Chinese Atherosclerosis Society
Major Research Interest:
Molecular Mechanisms of Cardiac Hypertrophy and Heart Failure
Gene and Cell Therapy for Myocardial Infarction and Heart Failure
Regenerative Medicine and its application in Cardiovascular Diseases
Main Publications
1. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature. 2007 Mar 22;446(7134):444-8.（合作研究）
2. Wang X, Zou Y, Sun A, Xu D, Niu Y, Wang S, Wang K, Ge J. Emodin Induces Growth Arrest and Death of Human Vascular Smooth Muscle Cells Through Reactive Oxygen Species and p53. J Cardiovasc Pharmacol. 2007 May;49(5):253-260.
3. Zhang S, Ge J, Zhao L, Qian J, Huang Z, Shen L, Sun A, Wang K, Zou Y. Host vascular niche contributes to myocardial repair induced by intracoronary transplantation of bone marrow CD34+ progenitor cells in infarcted swine heart. Stem Cells. 2007 Feb 1.
4. Yang W, Ge J, Liu H, Zhao K, Liu X, Qu X, Li W, Huang Y, Sun A, Zou Y. Arsenic Trioxide Eluting Stent Reduces Neointima Formation in a Rabbit Iliac Artery Injury Mode. Cardiovascu Res. 2006, 72:483-93.
5. Ge J, Li Y, Qian J, Shi J, Wang Q, Niu Y, Fan B, Liu X, Zhang S, Sun A, Zou Y. Efficacy of Emergent Transcatheter Transplantation of Stem Cells for Treatment of Acute Myocardial Infarction (TCT-STAMI). Heart. 2006, 92:1764-7.
6. Zhang S, Ge J, Sun A, Xu D, Qian J, Lin J, Zhao Y, Hu H, Li Y, Wang K, Zou Y. Comparison of various kinds of bone marrow stem cells for the repair of infarcted myocardium: Single clonally purified non-hematopoietic mesenchymal stem cells serve as a superior source, J Cell Biochem. 2006, 99:1132-47.
7. Akazawa H, Zou Y, Komuro I. A novel mechanism of mechanical stress-induced hypertrophy. Novartis Found Symp. 2006, 274:20-31.
8. Wang X, Ge J, Wang K, Qian J, Zou Y. Evaluation of MTT assay for measurement of emodin-induced cytotoxicity. Assay Drug Dev Technol. 2006, 4:203-7.
9. Ge J, Jia Q, Liang C, Luo Y, Huang D, Sun A, Wang K, Zou Y, Chen H. Advanced glycosylation end products might promote atherosclerosis through inducing the immune maturation of dendritic cells. Arterioscler Thromb Vasc Biol. 2005, 25:2157-63.
10. Niu YH, Ge J, Xu CF, Shi JH, Jin XJ, Qian JY, Zou Y. Impact of pathogen burden on in-stent restenosis in patients after coronary stent implantation. Chin Med J (Engl). 2005, 118:1786-90.
11. Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi JI, Iwanaga K, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat. Med., 2005; 11:305－311.
12. Ma J, Ge J, Zhang S, Sun A, Shen J, Chen L, Wang K, Zou Y. Time course of myocardial stromal cell-derived factor 1 expression and beneficial effects of intravenously administered bone marrow stem cells in rats with experimental myocardial infarction. Basic Res. Cardiol. 2005; 100:217-223.
13. Hasegawa H, Takano H, Zou Y, Qin Y, Hizukuri K, Odaka K, Toyozaki T, Komuro I. Pioglitazone, a peroxisome-proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance. J Mol Cell Cardiol. 2005; 38:257-265.
14. Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Sakamoto M, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat. Cell Biol.; Article, 2004 ; 6:499-506.
15. Takano H, Hasegawa H, Zou Y, Komuro I. Pleiotropic actions of PPAR gamma activators thiazolidinediones in cardiovascular diseases. Curr. Pharm. Des. 2004;10:2779-2786.
16. Ohtsuka M, Takano H, Zou Y, Toko H, Akazawa H, Qin Y, Suzuki M, Hasegawa H, Nakaya H, Komuro I. Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization. FASEB J. 2004; 18:851-853.
17. Toko H, Zou Y, Minamino T, Sakamoto M, Sano M, Harada M, Nagai T, Sugaya T, Terasaki F, Kitaura Y, Komuro I. Angiotensin II Type 1a Receptor Is Involved in Cell Infiltration, Cytokine Production, and Neovascularization in Infarcted Myocardium. Arterioscler. Thromb. Vasc. Biol. 2004; 24:664-670.
18. Zou Y, Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A and Komuro I. Heat Shock Transcription Factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation 2003; 108:3024-3030.
19. Takano H, Zou Y, Hasegawa H, Akazawa H, Nagai T, Komuro I. Oxidative Stress-Induced Signal Transduction Pathways in Cardiac Myocytes: Involvement of ROS in the heart Diseases. Antioxidant. Redox. Signal. 2003; 5:789-794.
20. Zou Y, Takano H, Mizukami M, Akazawa H, Qin Y, Toko H, Sakamoto M, Minamino T, Nagai T, Komuro I. Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction. Circulation 2003; 108:784-753.
21. Zou Y, Yamazaki T, Nakagawa K, Yamada H, Iriguchi N, Toko H, Takano H, Akazawa H, Nagai R, Komuro I. Continuous Blockade of L-Type Ca2+ Channels Suppresses Activation of Calcineurin and Development of Cardiac Hypertrophy in Spontaneously Hypertensive Rats. Hypertens. Res. 2002; 25:117-124.
22. Takano H, Zou Y, Akazawa H, Toko H, Mizukami M, Hasegawa H, Asakawa M, Nagai T, Komuro I. Inhibitory Molecules in Signal Transduction Pathways of Cardiac Hypertrophy. Hypertens. Res. 2002; 25:491-498.
23. Toko H, Oka T, Zou Y, Sakamoto M, Mizukami M, Sano M, Yamamoto R, Sugaya T, Komuro I. Angiotensin II Type 1a Receptor Mediates Doxorubicin-Induced Cardiomyopathy. Hypertens. Res. 2002; 25:597-603.
24. Zou Y, Takano H, Akazawa H, Nagai T, Mizukami M, Komuro I. Molecular and Cellular Mechanisms of Mechanical Stress-Induced Cardiac Hypertrophy. Endocrine J. 2002; 49:1-13
25. Aikawa R, Nagai T, Kudoh S, Zou Y, Tanaka M, Tamura M, Akazawa H, Takano H, Nagai R, Komuro I. Integrins Play a Critical Role in Mechanical Stress-Induced p38 MAPK Activation. Hypertension 2002; 39:233-238.
26. Zou Y, Nagai R, Yamazaki T. Urotensin II induces hypertrophic responses in cultured cardiomyocytes from neonatal rats. FEBS Lett. 2001; 508:57-60.
27. Gu Y, Zou Y, Aikawa R, Hayashi D, Kudoh S, Yamauchi T, Uozumi H, Zhu W, Kadowaki T, Yazaki Y, Komuro I. Growth hormone signalling and apoptosis in neonatal rat cardiomyocytes. Mol. Cell. Biochem. 2001; 223:35-46.
28. Zou Y, Yao A, Zhu W, Kudoh S, Hiroi Y, Shimoyama M, Uozumi H, Kohmoto O, Takahashi T, Shibasaki F, Nagai R, Yazaki Y, Komuro I. Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation 2001; 104:102-108.
29. Zou Y, Hiroi Y, Uozumi H, Takimoto E, Toko H, Zhu W, Kudoh S, Mizukami M, Shimoyama M, Shibasaki F, Nagai R, Yazaki Y, Komuro I. Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation 2001; 104:97-101.
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