抗氧化剂普罗布考对细胞介导的

体外和体内LDL氧化的作用

Bilenko MV etal. Bull Exp Biol Med, 2003 ;136(2):126-8

我们研究了酚性抗氧化剂普罗布考对健康体血清LDL的游离基氧化的作用。LDL与培养的局部缺血再灌注条件的外周血单核细胞巨噬细胞和人脐静脉内皮细胞共孵育致氧化。另外，试验了普罗布考对CHD患者血清LDL氧化的作用。普罗布考（0.1～10mM）有效地预防体外和体内LDL的游离基氧化。

Bull Exp Biol Med. 2003 Aug;136(2):126-8.  Related Articles, Links

Effect of antioxidant probucol on cell-mediated LDL oxidation in vitro and in vivo.

Bilenko MV, Khil'chenko AV, Konovalova GG, Lankin VZ.

V. N. Orekhovich State Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow.

We studied the effect of phenol antioxidant probucol on free radical oxidation of LDL isolated from blood plasma of healthy donors. Oxidation was induced by co-incubation of LDL with cultured peripheral blood monocyte-macrophages and human umbilical vein endothelial cells under conditions of ischemia-reperfusion. In addition, the effect of probucol therapy on oxidability of plasma LDL in CHD patients was examined. Probucol (0.1-10 microM) efficiently protected LDL from free radical oxidation in vitro and in vivo.

PMID: 14631489 [PubMed - in process]